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Ischemic postconditioning (Post C), which involves administration of a brief ischemia after the initial ischemic event, has been demonstrated to be strongly neuroprotective against global cerebral ischemia (GCI) and to improve cognitive outcome. To enhance understanding of the underlying mechanisms, the current study examined the role of NMDA receptors in mediating the beneficial effects of Post C...
Global cerebral ischemia, such as occurs following cardiac arrest, can lead to oxidative stress, hippocampal neuronal cell death, and cognitive defects. The current study examined the potential beneficial effect and underlying mechanisms of post‐treatment with the naturally occurring isoflavonic phytoestrogen, genistein, which has been implicated to attenuate oxidative stress. Genistein (1 mg kg−1...
In this study, we employed 1α‐hydroxylase knockout (1α‐(OH)ase−/−) mice to investigate the influence of 1,25‐dihydroxy vitamin D3 (1,25‐(OH)2D3) deficiency on the adult neurogenesis in the hippocampal dentate gyrus (DG). The numbers of both 24‐hr‐old BrdU+ cells and proliferating cell nuclear antigen positive cells in 8‐week‐old 1α‐(OH)ase−/− mice increased approximately twofold compared with wild‐type...
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