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Background: The fate of autoreactive T cells exposed to extrathymic self-antigen is examined in a double transgenic (DTG) mouse [(L d+ cardiacx2C)F1], where cardiac myocytes alone express L d and T cells express an antigen receptor (2C TCR) against L d . Methods: Naive cardiac L d+ single transgenic (STG) mice (before breeding with 2C) and DTG mice were examined...
Background: Administration of alloantigen via the portal vein (PV) in non-transgenic animals has been shown to promote immunologic tolerance and enhance transplant allograft survival. The underlying mechanisms remain unclear. In 2Cxdm2 F1 (2CF1) transgenic mice, the monoclonal antibody, 1B2, identifies specific 2C TCR transgenic CD8+ T cells that are cytotoxic against Class I MHC L d . In...
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