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Antigen injected subcutaneously (SQ) results in a strong systemic immune response, whereas antigen infused orally or by the portal vein tends to induce tolerance. Nontransgenic C57BL/6J (H-2 b ), or B6, mice and transgenic 2C mice (that express a cytotoxic T cell receptor against major histocompatibility complex Class I L d ) were used to investigate the regional and systemic responses...
Background. After monoclonal antibody or donor-specific transfusion treatment, infectious tolerance to rat or mouse heart or skin transplants can be passed on to naive recipients by adoptive transfer of tolerant lymphocytes. We examined whether similar regulatory cells develop after the spontaneous acceptance of Lewis-to-Dark Agouti (DA) rat liver transplants without immunomodulating agents. Methods...
Background. ''Infectious tolerance'' has been defined as the tolerance induced in a new recipient by the adoptive transfer of cells from a recipient accepting an allograft after anti-CD4 and anti-CD8 monoclonal antibody treatment. A clear understanding of the mechanisms responsible for graft acceptance after donor-specific blood transfusion (DST) has remained elusive. We examined the development and...
Background. C57BL/6 mice transfected with the L d gene coupled to the α-myosin heavy chain promoter result in transgenic mice with L d antigen expressed only on cardiac tissue. These transgenic animals allow the examination of immune reactivity against cardiac L d by ''self'' or by adoptively transferred L d specific 2C cells, and the response of nontransgenic C57BL/6...
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