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Methods for turning on/off gene expression at any desired time and place in vivo would be useful for analyzing various biological processes. We have developed a novel microscopic system utilizing an infrared laser, IR-LEGO (infrared-laser evoked gene operator), which is designed to deposit heat locally in living organisms. We have shown that IR-LEGO enables us to induce the heat shock response efficiently...
Methods for turning on and off gene expression at the experimentalist's discretion would be useful for analyzing various biological processes. They would also serve as valuable tools for manipulating biological processes in living organisms. We have been developing a novel microscopic system utilizing an infraredinfrared laser laser, IR-LEGO (infrared-laser evoked gene operator), which is designed...
Ectopic expression via transgene is powerful means for functional analysis of genes of multicellular organisms in vivo. Use of tissue-specific promoters for ectopic expression is limited by their inherent properties to drive gene expression in a restricted temporal-spatial expression pattern. We have developed a novel microscopic system utilizing an infrared laser, IR-LEGO (infrared-laser evoked gene...
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