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The ring opening of the cyclic prochiral cis-1,2,3,6-tetrahydrophthalic anhydride 1 with methanol was investigated by using cinchona alkaloids such as quinine (QN) and quinidine (QD) as base catalysts. The effect of solvent, temperature, reaction time and catalyst amount on the yield and enantioselectivity was examined in the model reaction under homogeneous conditions. The best results (yields and...
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