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Vagal nerve stimulation (VNS) induces bradycardia in chronic heart failure (CHF). We hypothesized that beta-blocker would cover the beneficial effects of VNS on CHF if the anti-beta-adrenergic effect was the main VNS effect. This study investigated the effects of VNS on cardiac remodeling in rats with CHF treated with metoprolol. Two weeks after myocardial infarction, surviving rats were randomly...
Our previous study showed that chronic vagal stimulation (VS) prevented the cardiac remodeling and improved the prognosis of chronic heart failure (CHF) rats after large myocardial infarction (MI). Antiarrhythmic effects of VS were assumed to produce such a beneficial outcome. Therefore, we examined the effects of VS on cardiac arrhythmias. The ECG transmitter and a radio-controlled stimulator were...
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