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The purpose of this study was to determine whether apoptosis in placenta was affected by IFNγ, which can induce abortion, and whether the effect of IFNγ on apoptosis resulted from an intrinsic program of apoptosis, which was regulated by Bcl-2 and Bax. DNA fragmentation analysis indicated that cleavage of DNA into 180 bp and its polymers were recognized in placenta in control and IFNγ treated groups...
To investigate the possible mechanisms by which interferon gamma (IFNγ) affects pregnancy, the expression of class II major histocompatibility complex (MHC) antigens and cleavage of DNA that is a hallmark of apoptosis in the placenta were examined by molecular biochemical techniques, and progesterone levels were examined by radioimmunoassay. The semi-quantitative analysis with reverse transcription-polymerase...
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