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Ultrasound‐targeted microbubble destruction (UTMD) mediates gene transfection with high biosafety and thus has been promising toward treatment of type 1 diabetes. However, the potential application of UTMD in type 2 diabetes (T2D) is still limited, due to the lack of systematic design and dynamic monitoring. Herein, an efficient gene delivery system is constructed by plasmid deoxyribonucleic acid...
Objective To investigate the feasibility of ultrasound (US) mediated enhanced green fluorescent protein (EGFP) gene delivery in subcutaneous transplanted tumors of human cervical carcinoma (Hela) and the contribution of lipid shell microbubble (LSMB) on gene transfection. Methods LSMB and plasmid were injected into nude mice by tail vein followed local US irradiation (P + LSMB + US group). US exposure...
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