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Diabetes is a significant public health issue known as the world's fastest‐growing disease condition. It is characterized by persistent hyperglycemia and subsequent chronic complications leading to organ dysfunction and, ultimately, the failure of target organs. Substance P (SP) is an undecapeptide that belongs to the family of tachykinin (TK) peptides. The SP‐mediated activation of the neurokinin...
The neuropeptide substance P (SP) triggers a variety of tumor‐promoting signaling pathways through the activation of neurokinin‐1receptor (NK1R), a class of neurokinin G protein‐coupled receptors superfamily. Recent researches in our and other laboratories have shown the overexpression of both SP and NK1R in breast cancer (BC) patients. SP/NK1R signaling is strongly implicated in the pathogenesis...
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