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IL‐1 is a key cytokine known to drive chronic inflammation and to regulate many physiological, immunological, and neuroimmunological responses via actions on diverse cell types of the body. To determine the mechanisms of IL‐1 actions as part of the inflammatory response in vivo, we generated a conditional IL‐1 receptor 1 (IL‐1R1) mouse mutant using the Cre/LoxP system (IL‐1R1fl/fl). In the mutant...
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