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Lymph node metastasis (LNM) is a significant barrier to the prognosis of patients with gastric cancer (GC). Helicobacter pylori (H. pylori)‐positive GC patients experience a higher rate of LNM than H. pylori‐negative GC patients. However, the underlying mechanism remains unclear. Based on the findings of this study, H. pylori‐positive GC patients have greater lymphangiogenesis and lymph node immunosuppression...
Due to the increased integration and miniaturization of electronic devices, traditional electronic packaging materials, such as epoxy resin (EP), cannot solve electromagnetic interference (EMI) in electronic devices. Thus, the development of multifunctional electronic packaging materials with superior electromagnetic wave absorption (EMA), high heat dissipation, and flame retardancy is critical for...
Fabricating bio‐latex colloids with core–shell nanostructure is an effective method for obtaining films with enhanced mechanical characteristics. Nano‐sized lignin is rising as a class of sustainable nanomaterials that can be incorporated into latex colloids. Fundamental knowledge of the correlation between surface chemistry of lignin nanoparticles (LNPs) and integration efficiency in latex colloids...
Blood–Brain Barrier Therapy
The blood–brain barrier (BBB) is a bottleneck in the treatment of brain tumors. In article number 2203678, Liang Wang, Yinyan Wang, Lin Feng, and co‐workers summarize the current approaches to overcome the BBB, such as the use of “Trojan horse” molecular modifications for deception, and describe a variety of micro‐nanocarriers for targeted brain tumor therapy.
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB), making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely and effectively penetrate the BBB to achieve targeted drug delivery to brain tumors has been a challenging research problem. With the intensive research in micro‐ and nanotechnology in recent years, nano drug‐targeted...
Micromanipulation
In article number 2105414, Xue Bai, Lin Feng, and co‐workers develop a magnetically actuated cell‐robot system for micromanipulation. The robots exhibit high position control accuracy and generate a flow field that can be used to transport microspheres and cells using an external rotating magnetic field. The cell robots can also form chain‐like swarms to transport a large object...
Border‐nearing microrobots with self‐propelling and navigating capabilities have promising applications in micromanipulation and bioengineering, because they can stimulate the surrounding fluid flow for object transportation. However, ensuring the biosafety of microrobots is a concurrent challenge in bioengineering applications. Here, macrophage template‐based microrobots (cell robots) that can be...
Although incorporating multiple halogen (bromine) anions and alkali (rubidium) cations can improve the open‐circuit voltage (Voc) of perovskite solar cells (PSCs), severe voltage loss and poor stability have remained pivotal limitations to their further commercialization. In this study, acetylcholine (ACh+) is anchored to the surface of a quadruple‐cation perovskite to provide additional electron...
Cell Robots for Tumor Therapy
In article number 2103986, Huawei Chen, Lin Feng, and co‐workers develop a cell robot system for targeted tumor therapy by converting biological cells through endocytosis of functionalized iron nanoparticles. The robot uses a combination of the macrophage's tumor‐tropism and external magnetic control for navigation to tumors through the blood vessels. With the cascaded...
Injecting micro/nanorobots into the body to kill tumors is one of the ultimate ambitions for medical nanotechnology. However, injecting current micro/nanorobots based on 3D‐printed biocompatible materials directly into blood vessels for targeted therapy is often difficult, and mistakes in targeting can cause serious side effects, such as blood clots, oxidative stress, or inflammation. The natural...
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