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Cerebellar granule cells (GCs) account for more than half of all neurons in the CNS of vertebrates. Theoretical work has suggested that the abundance of GCs is advantageous for sparse coding during memory formation. Here, we minimized the output of the majority of GCs by selectively eliminating their Ca V 2.1 (P/Q-type) Ca 2+ channels, which mediate the bulk of their neurotransmitter...
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