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We investigated the role of epithelium in smooth muscle contraction induced by leukotriene D 4 (LTD 4 ) in isolated human trachea. The contractile response to LTD 4 was potentiated by an inhibitor of dipeptidases l-cysteine and by removal of the epithelium. Both l-cysteine (3 10 -3 M) and removal of the epithelium shifted the concentration-response curves...
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