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OBJECTIVE
Our studies in vitro and in vivo aimed to investigate the influence of DNA methylation of peroxisome proliferator activated receptor‐α (PPAR‐α) gene in non‐alcoholic fatty liver disease (NAFLD) pathogenesis and to observe whether the DNA methylation inhibitor 5‐Aza‐2'‐deoxycytidine (5‐Aza‐CdR) and the herbal medicine curcumin might reverse the effect both in vivo and in vitro.
METHODS...
Objective
To investigate the role of adiponectin precursor (ADIPOQ) DNA methylation in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the effect of curcumin on the development of NAFLD using rat models.
Methods
Male Sprague–Dawley rats were divided into the control, NAFLD and curcumin‐treated groups. The genetic and epigenetic features of each rat were measured and recorded. Real‐time...
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