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Leukotriene B4 (LTB 4 ) is a potent inflammatory mediator in asthma, and is increased in more severe asthma. Targeting LTB 4 , in addition to cysteinyl leukotrienes, could be beneficial in asthma.This was a randomized, double-blind trial of once-daily MK-0633, a potent 5-lypoxygenase inhibitor, 10 mg, 50 mg, and 100 mg, and placebo in patients 18–70 years with a history of chronic...
Chronic obstructive pulmonary disease (COPD) is associated with neutrophil-mediated inflammation, a potential target for treatment in COPD. We evaluated MK-0633, a 5-lipoxygenase inhibitor in patients with COPD.This was a 12 week, randomized, double-blind, multicenter study comparing MK-0633 100 mg and placebo in patients 40–75 years of age (N = 266) with COPD, post-β-agonist forced expiratory volume...
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