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This study aims to determine whether caveolin‐1 (Cav‐1) participates in the process of diabetic neuropathic pain by directly regulating the expression of toll‐like receptor 4 (TLR4) and the subsequent phosphorylation of N‐methyl‐D‐aspartate receptor 2B subunit (NR2B) in the spinal cord. Male Sprague‐Dawley rats (120–150 g) were continuously fed with high‐fat and high‐sugar diet for 8 weeks, and received...
Purpose The aim of the present study was to further elucidate the role of JAK2/STAT3-CAV-1-NR2B on painful diabetic neuropathy. Methods In vivo, the mechanical withdrawal threshold and thermal withdrawal latency were measured to evaluate neuropathic pain behaviors (n= 8), while western blot (n= 5) and an immunofluorescence double staining experiment (n= 6) were performed to understand the molecular...
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