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Background Recent studies have shown a crucial role of Gαq in immune regulation, but how Gαq modulates regulatory B-cell (Breg) function is still unclear. We address this here. Methods CD19+IL-10+ Bregs of wild-type (WT) and Gnaq−/− mice were analyzed by flow cytometry after stimulation by lipopolysaccharide. The WT and Gnaq−/− Bregs were isolated and cocultured with WT CD4+CD25− T cells in the...
Background Gout is considered one of the most painful acute conditions caused by deposition of monosodium urate (MSU) crystals within joints. Recent studies have shown that interleukin (IL)-1β is a key inflammatory mediator in acute gouty arthritis (GA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanisms of the regulation remain unclear. Methods A miRNA microarray...
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