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Methylmercury (MeHg) is a potent neurotoxin,which leads to a wide range of intracellular effects. The molecular mechanismsassociated to MeHg‐induced neurotoxicity have not been fully understood.Oxidative stress, as well as synaptic glutamate (Glu) dyshomeostasis have beenidentified as two critical mechanisms during MeHg‐mediated cytotoxicity. Here,we developed a rat model of MeHg poisoning to evaluate...
Methylmercury (MeHg), an extremely dangerous environmental pollutant, accumulating preferentially in central nervous system, causes a series of cytotoxic effects. The present study explored the mechanisms which contribute to MeHg‐induced neurotoxicity focusing on the oxidative stress in rat cerebral cortex. In addition, the protective effects of alpha‐lipoic acid (LA), a potent antioxidant on MeHg‐mediated...
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