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By enhancing the speed, accuracy, and sensitivity, it opens up a new possibility for direct analysis of biologically relevant entities such as nucleic acids and proteins in single cell level. Nanofluidic systems with critical dimensions which were comparable to the molecular scales can provide the aforementioned performance, offering a novel basis for ultrasensitive and high-resolution bio-detections...
In this paper, biomolecular electropreconcentration has been demonstrated in a hybrid micro/nano-fluidic device incorporated with multi-wall-carbon-nanotubes (MWCNTs) array. Parylene (poly(p-xylylene) was deposited on MWCNTs walls as a dielectric material, the surface charge characters and density could adjusted when an induced polarizes filed was applied. The competition between electroosmotic dragging...
This paper proposes a novel design of a reusable biosensor for in-situ and continuous protein detection. The sensing probe was practiced by the integration of a fiber optic interferometry (FOI) sensor accommodated in a micro opto-fluidic chip covered with a microdialysis membrane and surface regeneration mechanism for regenerable detection. Gold-nanoparticles (GNPs) labeled anti-rabbit IgG was used...
This paper proposes a needle-type biosensor for immunological application, which combines the abilities of real-time monitoring, in-situ measurement and high sensitivity, by adopting gold-nanoparticles (GNPs) coated with antibody to enhance the signal of Fabry-Perot (F-P) interferometry in an optic fiber sensing system. Strong reflection induced by larger index mismatch and longer optical path from...
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