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Halogenation of organic semiconductors is an efficient strategy for improving the performance of organic solar cells (OSCs), while the introduction of halogens usually involves complex synthetic process and serious environment pollution problems. Herein, three halogen‐free ternary copolymer donors (PCNx, x = 3, 4, 5) based on electron‐withdrawing dicyanobenzotriazole are reported. When blended with...
Developing dynamic and highly sensitive methods for imaging M2‐type tumor‐associated macrophages (TAMs) is vital for monitoring the tumor progression and assessing the therapeutic efficacy. Here, the fabrication and application of rationally designed Er‐based rare‐earth nanoprobes for the targeted imaging of M2‐type TAMs in glioblastoma (GBM) through the second near‐infrared (NIR‐II) fluorescence...
Autophagy
To overcome the autophagy compromised mechanism of protective cellular processes by “eating” damaged organelles or potentially toxic materials in tumor cells, Nan Li and co‐workers show how tellurium double‐headed nanobullets (TeDNBs)‐HO is utilized to induce autophagy dysfunction. On the one hand, TeDNBs‐mediated endoplasmic reticulum stress could excessively induce autophagy; thus, resulting...
To overcome the autophagy compromised mechanism of protective cellular processes by “eating”/“digesting” damaged organelles or potentially toxic materials with autolysosomes in tumor cells, lysosomal impairment can be utilized as a traditional autophagy dysfunction route for tumor therapy; however, this conventional one‐way autophagy dysfunction approach is always limited by the therapeutic efficacy...
Owing to the interacted anion and cation redox dynamics in Li2MnO3, the high energy density can be obtained for lithium‐rich manganese‐based layered transition metal (TM) oxide [Li1.2Ni0.2Mn0.6O2, LNMO]. However, irreversible migration of Mn ions and oxygen release during highly de‐lithiation can destroy its layered structure, leading to voltage and capacity decline. Herein, non‐TM antimony (Sb) is...
In article number 1901065, Haiyan Li, Ruxandra Gref, Jiwen Zhang, and co‐workers present the template‐guided synthesis and immobilization of ultrafine silver nanoparticles within cyclodextrin metal–organic frameworks to control the particle size and enhance stability. The Gly‐Arg‐Gly‐Asp‐Ser (GRGDS) functionalization can integrate the antibacterial property of silver nanoparticles with hemostasis...
The challenge of bacterial infection increases the risk of mortality and morbidity in acute and chronic wound healing. Silver nanoparticles (Ag NPs) are a promising new version of conventional antibacterial nanosystem to fight against the bacterial resistance in concern of the drug discovery void. However, there are several challenges in controlling the size and colloidal stability of Ag NPs, which...
Synergistic integration of two active metal‐based compounds can lead to much higher electrocatalytic activity than either of the two individually, due to the interfacial effects. Herein, a proof‐of‐concept strategy is creatively developed for the successful fabrication of twinned tungsten carbonitride (WCN) nanocrystals, where W2C and WN are chemically bonded at the molecule level. High‐angle annular...
Enzyme as signal tag has been widely employed in colorimetric immunoassays for decades. Nevertheless, it remains a great challenge to substantially improve the detection sensitivity of enzyme‐based immunoassays, which inhibits further critical applications. To circumvent this confinement, a multifunctional self‐assembled proteinosome based on the integration of signal amplification elements (enzyme)...
Conventional chemotherapy shows moderate efficiency against metastatic cancer since it targets only part of the mechanisms regulating tumor growth and metastasis. Here, gold nanorod (GNR)‐based host‐guest nanoplatforms loaded with docetaxel (DTX) and small interfering RNA (siRNA)‐p65 (referred to as DTX‐loaded GNR (GDTX)/p65) for chemo‐, RNA interference (RNAi), and photothermal ablation (PTA) cooperative...
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