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Although it is widely recognized that the osteoclast differentiation induced by RANKL is linked to the anti-proliferative activity of the cytokine, we report here that RANKL in the presence of M-CSF actually stimulates DNA synthesis and cell proliferation during the early proliferative phase (0–48h) of osteoclastogenesis ex vivo, while the same cytokine exerts an anti-proliferative activity in the...
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