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RsmI and RsmH are AdoMet‐dependent methyltransferases that are responsible for the 2′‐O‐methylation and N4‐methylation of C1402 of Escherichia coli 16S rRNA, respectively. Modification of this site has been found to play a role in fine‐tuning the shape and function of the P‐site to increase the decoding fidelity. It is interesting to study the mechanism by which C1402 can be methylated by both RsmI...
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