Wyniki wyszukiwania dla: Parham Taslimi

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Peripheral (E)‐2‐[(4‐hydroxybenzylidene)‐3,4‐dihydronaphthalen‐1(2H)‐one)]‐coordinated phthalocyanines with improved enzyme inhibition properties and photophysicochemical behaviors

Özcan Güleç, Ahmet T. Bilgiçli, Burak Tüzün, Parham Taslimi, więcej

Archiv der Pharmazie > 357 > 9 > n/a - n/a

In this study, (E)‐4‐{4‐[(1‐oxo‐3,4‐dihydronaphthalen‐2(1H)‐ylidene)methyl]phenoxy}phthalonitrile (4) and its phthalocyanine derivatives (5–8) were synthesized for the first time. Aggregation behaviors of the novel soluble phthalocyanines in organic solvents were investigated. In addition, the efficiency of ¹O₂ production of (5) and ZnPc (6) was investigated. The singlet oxygen quantum yields (Φ_Δ)...

artykuł

Synthesis of the chromone‐thiosemicarbazone scaffold as promising α‐glucosidase inhibitors: An in vitro and in silico approach toward antidiabetic drug design

Rima D. Alharthy, Sana Khalid, Shamool Fatima, Saeed Ullah, więcej

Archiv der Pharmazie > 357 > 8 > n/a - n/a

Diabetes is a serious metabolic disorder affecting individuals of all age groups and prevails globally due to the failure of previous treatments. This study aims to address the most prevalent form of type 2 diabetes mellitus (T2DM) by reporting on the design, synthesis, and in vitro as well as in silico evaluation of chromone‐based thiosemicarbazones as potential α‐glucosidase inhibitors. In vitro...

artykuł

Synthesis, biological activities, and molecular docking studies of triazolo[4,3‐b]triazine derivatives as a novel class of α‐glucosidase and α‐amylase inhibitors

Soheila Seyfi, Somayeh Salarinejad, Setareh Moghimi, Mahsa Toolabi, więcej

Archiv der Pharmazie > 357 > 7 > n/a - n/a

In diabetes mellitus, amylase and glucosidase enzymes are the primary triggers. The main function of these enzymes is to break macromolecules into simple sugar units, which directly affect blood sugar levels by increasing blood permeability. To overcome this metabolic effect, there is a need for a potent and effective inhibitor capable of suppressing the enzymatic conversion of sugar macromolecules...

artykuł

New Azo Derivative of β‐Diketones and Its Cu(II), Co(II) Complexes: Synthesis, Theoretical Study and Biological Activity

Shahla Tahirli, Nastaran Sadeghian, Farqana Aliyeva, Afsun Sujayev, więcej

Chemistry & Biodiversity > 21 > 4 > n/a - n/a

The paper is focused on biological activity and theoretical study of the structure and properties of a new azo derivative of β‐diketones and its complexes with some metals. The aim of our work was to study the structure and properties of the newly synthesized compound as well as to theoretically determine the possibility of complex formation with the Cu(II) or Co(II) ions. A compound with the same...

artykuł

Ugi four‐multicomponent reaction based synthesis, in vitro, and in silico enzymatic evaluations of new pyrazino[1,2‐a]indole‐1,4‐dione‐indole‐2‐phenylacetamides as potent inhibitors against α‐glucosidase and α‐amylase

Fatemeh Ahmadi Shourkaei, Parviz Rashidi Ranjbar, Parham Taslimi, Mohammad Mahdavi

Chemistry & Biodiversity > 21 > 2 > n/a - n/a

In this work, synthesis and evaluation of pyrazino[1,2‐a]indole‐1,4‐dione‐indole‐2‐phenylacetamides 6 a–k as new synthetic anti‐diabetes agents were presented. These compounds were synthesized by a four‐component Ugi reaction without metal catalyst. All synthesized compounds were evaluated against α‐glucosidase and α‐amylase as two important targets in the treatment of diabetes. Approximately, all...

artykuł

Synthesis of 3‐hydroxy‐2‐naphthohydrazide‐based hydrazones and their implications in diabetic management via in vitro and in silico approaches

Mussarat Tasleem, Saeed Ullah, Sobia Ahsan Halim, Ifra Urooj, więcej

Archiv der Pharmazie > 357 > 2 > n/a - n/a

Diabetes mellitus (DM) has prevailed as a chronic health condition and has become a serious global health issue due to its numerous consequences and high prevalence. We have synthesized a series of hydrazone derivatives and tested their antidiabetic potential by inhibiting the essential carbohydrate catabolic enzyme, “α‐glucosidase.” Several approaches including fourier transform infrared, ¹H NMR,...

artykuł

New palladium complexes with N‐heterocyclic carbene and morpholine ligands: Synthesis, characterization, crystal structure, molecular docking, and biological activities

Ayten Behçet, Parham Taslimi, Betül Şen, Tuğba Taskın‐Tok, więcej

Journal of Biochemical and Molecular Toxicology > 38 > 1 > n/a - n/a

This work includes the synthesis of a new series of palladium‐based complexes containing both morpholine and N‐heterocyclic carbene (NHC) ligands. The new complexes were characterized using NMR (¹H and ¹³C), FTIR spectroscopic, and elemental analysis techniques. The crystal structure of complex 1b was obtained by utilizing the single‐crystal X‐ray diffraction method. X‐ray studies show that the coordination...

artykuł

Novel hydrazones derived from anthranilic acid as potent cholinesterases and α‐glycosidase inhibitors: Synthesis, characterization, and biological effects

Feyzi Sinan Tokalı, Parham Taslimi, Tugba Taskin‐Tok, Ahmet Karakuş, więcej

Journal of Biochemical and Molecular Toxicology > 38 > 1 > n/a - n/a

N‐substitued anthranilic acid derivatives are commonly found in the structure of many biologically active molecules. In this study, new members of hydrazones derived from anthranilic acid (1−15) were synthesized and investigated their effect on some metabolic enzymes such as acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glycosidase (α‐Gly). Results indicated that all the molecules...

artykuł

Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1,3,4‐thiadiazole derivatives

Tenzile Alagöz, Fatma Güneş Çalişkan, Hayriye Genç Bilgiçli, Mustafa Zengin, więcej

Archiv der Pharmazie > 356 > 12 > n/a - n/a

A series of carvacrol‐based thiosemicarbazide (3a–e) and 1,3,4‐thiadiazole‐2‐amine (4a–e) were designed and synthesized for the first time. The structures were characterized by nuclear magnetic resonance and high resolution mass spectroscopy techniques. All compounds were examined for some metabolic enzyme activities. Results indicated that all the synthetic molecules exhibited powerful inhibitory...

artykuł

Biological Effects and Crystal X‐Ray Study of Novel Schiff Base Containing Pentafluorophenyl Hydrazine: In Vitro and in Silico Studies

Fatma Hamurcu, Ümmühan Özdemir Özmen, Ozan Sanlı Şentürk, Kerem Kaya, więcej

Chemistry & Biodiversity > 20 > 11 > n/a - n/a

A novel Schiff base namely 3,5‐di‐tert‐butyl‐6‐((2‐(perfluorophenyl)hydrazono)methyl)phenol was successfully synthesized and characterized using FT‐IR and ¹H‐NMR, ¹³C‐NMR, and ¹⁹F‐NMR. The crystal structure analysis of the Schiff base compound was also characterized with single crystal X‐ray diffraction studies and supported the spectroscopic results. The cytotoxicity, anti‐bacterial properties, and...

artykuł

Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus

Feyzi Sinan Tokalı, Parham Taslimi, Burak Tuzun, Ahmet Karakuş, więcej

Chemistry & Biodiversity > 20 > 10 > n/a - n/a

Quinazolinones, which represent an important part of nitrogen‐containing six‐membered heterocyclic compounds, are frequently used in drug design due to their wide biological activity properties. Therefore, the novel quinazolinones were synthesized from the reaction of acylated derivatives of 4‐hydroxy benzaldehyde with 3‐amino‐2‐alkylquinazolin‐4(3H)‐ones with good yields (85–94 %) and their structures...

artykuł

Synthesis and Biological Activity of Some Bromophenols and Their Derivatives Including Natural Products

Cetin Bayrak, Parham Taslimi, Namik Kilinc, Ilhami Gulcin, więcej

Chemistry & Biodiversity > 20 > 8 > n/a - n/a

In addition to the first synthesis of the natural bromophenol butyl 2‐(3,5‐dibromo‐4‐hydroxyphenyl)acetate (1), indene derivatives 34 and 35 were synthesized from 3‐phenylpropenal derivatives in BBr₃ medium. Five known natural bromophenols and some derivatives were synthesized by known methods. Cholinesterase (ChEs) inhibitors reduce the breakdown of acetylcholine and are used in the treatment of...

artykuł

Design, synthesis, α‐glucosidase inhibition, pharmacokinetic, and cytotoxic studies of new indole‐carbohydrazide‐phenoxy‐N‐phenylacetamide derivatives

Haleh Hamedifar, Maryam Mohammadi‐Khanaposhtani, Maedeh Sherafati, Milad Noori, więcej

Archiv der Pharmazie > 356 > 6 > n/a - n/a

A new series of indole‐carbohydrazide‐phenoxy‐N‐phenylacetamide derivatives 7a–l were designed, synthesized, and screened for their α‐glucosidase inhibitory abilities and cytotoxic effects. The results obtained in the α‐glucosidase inhibition assay indicated that most of the synthesized derivatives displayed good to moderate inhibitory abilities (K_i values ranging from 14.65 ± 2.54 to 37.466 ± 6.46...

artykuł

Synthesis and evaluation of novel xanthene‐based thiazoles as potential antidiabetic agents

Saira Naseem, Zahid Shafiq, Parham Taslimi, Saghir Hussain, więcej

Archiv der Pharmazie > 356 > 1 > n/a - n/a

A series of xanthene‐based thiazoles was synthesized and characterized by different scpectroscopic methods, i.e. Proton nuclear magnetic resonance (¹H NMR), carbon nuclear magnetic resonance (¹³C NMR), infrared spectroscopy, carbon hydrogen nitrogen analysis, and X‐ray crystallography. The inhibition potencies of 18 newly synthesized thiazole derivatives were investigated on the activities of acetylcholinesterase...

artykuł

New PEPPSI‐Pd‐NHC complexes bearing 4‐hydroxyphenylethyl group: Synthesis, characterization, molecular docking, and bioactivity properties

Ayten Behçet, Parham Taslimi, Yetkin Gök, Aydın Aktaş, więcej

Archiv der Pharmazie > 355 > 12 > n/a - n/a

Five 4‐hydroxyphenylethyl substituted pyridine enhanced, precatalyst, preparation, stabilization, and initiation‐Pd‐N‐heterocyclic carbene (PEPPSI‐Pd‐NHC) complexes are synthesized in a straightforward way. All PEPPSI‐Pd‐NHC complexes were prepared by mixing 4‐hydroxyphenylethyl substituted NHC precursors, palladium chloride, potassium carbonate, and potassium bromide in pyridine. All complexes were...

artykuł

A Biochemical Approach for Hedysarum candidissimum from Turkey: Screening Phytochemicals, Evaluation of Biological Activites, and Molecular Docking Study

Ahmet Altay, Esma Yeniceri, Parham Taslimi, Tugba Taskin‐Tok, więcej

Chemistry & Biodiversity > 19 > 9 > n/a - n/a

This study was designed to screen the phytochemical composition and investigate the biological activities of Hedysarum candidissimum extracts and also support the results with molecular docking studies. LC/MS/MS analysis revealed the presence of 22 phytochemical constituents (mainly phenolic acids, flavonoids, and flavonoid glycosides) in the plant structure. The methanol extract exhibited the strongest...

artykuł

Turanecio hypochionaeus: Determination of Its Polyphenol Contents, and Bioactivities Potential Assisted with in Silico Studies

Dursun Kısa, Rizvan Imamoglu, Zafer Kaya, Tugba Taskin‐Tok, więcej

Chemistry & Biodiversity > 19 > 9 > n/a - n/a

The aim of this study was to identify and quantify the phenolic composition of Turanecio hypochionaeus Bosse and determine the anti‐urease, anti‐lipase, antidiabetic, anti‐melanogenesis, antibacterial, and anti‐Alzheimer properties. IC₅₀ results for all enzymes were obtained between 0.234–116.50 μg/mL and this plant inhibited HMG_CoA R and glucosidase enzymes more with IC₅₀ values of 0.234 and 116...

artykuł

Some phenolic natural compounds as carbonic anhydrase inhibitors: An in vitro and in silico study

Ahmet Gokhan Aggul, Naim Uzun, Muslum Kuzu, Parham Taslimi, więcej

Archiv der Pharmazie > 355 > 6 > n/a - n/a

This paper presents experimental and molecular docking studies on the inhibitory effects of tyrosol, hydroxytyrosol, luteolin, diosmetin, caffeic acid, luteolin 7‐O‐glycoside, and apigenin 7‐O‐glycoside from olive (Olea europaea L.) leaf against human carbonic anhydrase (hCA, E.C.4.2.1.1) isozymes I and II. After these isozymes were separately purified, their activities were determined using the esterase...

artykuł

Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations

Hasan Yakan, Ümit M. Koçyiğit, Halit Muğlu, Mustafa Ergul, więcej

Journal of Biochemical and Molecular Toxicology > 36 > 5 > n/a - n/a

A new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform infrared, ¹H‐nuclear magnetic resonance (NMR), ¹³C‐NMR spectroscopic methods and elemental analysis. Cytotoxic effects of target compounds were determined by 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide...

artykuł

New 4‐phenylpiperazine‐carbodithioate‐N‐phenylacetamide hybrids: Synthesis, in vitro and in silico evaluations against cholinesterase and α‐glucosidase enzymes

Maryam Mohammadi‐Khanaposhtani, Milad Nori, Yousef Valizadeh, Shahrzad Javanshir, więcej

Archiv der Pharmazie > 355 > 5 > n/a - n/a

A series of novel 4‐phenylpiperazine‐carbodithioate‐N‐phenylacetamide hybrids (6a–n) was designed, synthesized, and evaluated for their in vitro inhibitory activity against the metabolic enzymes, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glucosidase. The obtained results showed that most of the synthesized compounds exhibited high to good anti‐AChE and anti‐BChE activity in...

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