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Osteoporosis is a common bone disease caused by an imbalance of bone resorption and formation that results in a loss of total bone density. SMAD2/3 signal transduction is known to play a crucial role in osteogenic differentiation through transforming growth factor‐beta (TGF‐β). By screening a library of small‐molecule compounds, the current study identifies higenamine (HG) as an active osteogenic...
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