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Background Global genomic hypomethylation is a common epigenetic event in cancer that mostly results from hypomethylation of repetitive DNA elements. Case–control studies have associated blood leukocyte DNA hypomethylation with several cancers. Because samples in case–control studies are collected after disease development, whether DNA hypomethylation is causal or just associated with cancer development...
MicroRNAs constitute a growing class of non-coding RNAs that are thought to regulate gene expression via translational repression in animal. Single nucleotide polymorphisms (SNPs) in microRNA may modify various biological processes by influencing the processing and/or target selection of microRNAs. Therefore, genetic background differences in distribution of micoRNA gene polymorphisms may be an important...
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