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The global burden of deaths caused by liver failure is substantial. The Asia‐Pacific region is home to more than half of the global population and accounted for 62.6% of global deaths because of liver diseases in 2015. The aetiology of liver failure varies in different countries at different times. Viruses (Hepatitis A, B and E), drugs (herbs and anti‐tuberculous drugs), toxins (alcohol use) and autoimmune...
Acute liver failure (ALF) plasma has cytotoxic effects on the cell‐loaded bioreactor in bioartificial liver support systems due to the presence of innumerable hepatotoxic compounds that adversely affect the morphology and functionality of the cells. We have designed a hybrid bioreactor that integrates a hepatic cell‐loaded cryogel disc and an activated carbon cloth in one compact unit, with potential...
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