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The strategy of incorporating both scaffold and drug delivery systems to promote tissue growth, has attracted increasing attention in the field of bone tissue engineering. The aim of this study was to incorporate dual microspheres with different diameters, based on chitosan (CS) and poly(lactide-co-glycolide) (PLGA), onto the porous surface of hydroxyapatite scaffolds (HAs). The scaffolds and microspheres...
Surface topography is known to regulate cellular behaviour including adhesion, proliferation and differentiation on 2d surfaces. It is remaining a challenge to integrate controlled surface topographies into pore surfaces of three-dimensional (3d) porous scaffolds for bone tissue engineering so as to direct the cell behaviour and inducing tissue growth. A novel and highly efficient method for integration...
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