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Background CCN1 plays distinct roles in various tumor types, but little is known regarding the role of CCN1 in leukemia. Methods We analyzed CCN1 protein expression in leukemia cell lines and in AML bone marrow samples. We also evaluated the effects of antibody- or siRNA-mediated inhibition of CCN1 on the growth of two AML cell lines (U937 and Kasumi-1 cells) and on the MEK/ERK pathway, β-catenin...
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