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Bladder cancer is a common malignancy in the urinary system. Defects of drug molecules in bladder during treatment, such as passive diffusion, rapid clearance of periodic urination, poor adhesion and permeation abilities, lead to low delivery efficiency of conventional drugs and high recurrence rate of disease. In this study, we designed multi‐responsive mesoporous polydopamine (PDA) composite nanorods...
Cancer Phototherapy
The endoplasmic reticulum (ER) plays an important role in protein synthesis, processing and secretion. ER‐targeting phototherapy significantly amplifies ER stress, promotes tumor antigen release, and elicits a robust immunogenic cell death. In article number 2202728 by Weidong Wang, Junping Wang, Shenglin Luo, and co‐workers, a small molecular heptamethine cyanine photosensitizer...
Cancer phototherapy activates immunogenic cell death (ICD) and elicits a systemic antitumor immune response, which is an emerging approach for tumor treatment. Most available photosensitizers require a combination of immune adjuvants or checkpoint inhibitors to trigger antitumor immunity because of the immunosuppressive tumor microenvironment and the limited phototherapeutic effect. A class of tumor‐targeting...
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