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Lysine acetylation, first identified in histones, was initially thought to be a posttranslational modification occuring only in eukaryotic cells that controlled gene transcription either via remodeling chromatin or altering the transcriptional machinery. Recent studies, however, have shown that acetylation is a well-conserved metabolic regulatory mechanism that plays critical roles in regulating and...
Recent developments in intermediary metabolic research show us that our understanding of intermediary metabolism is not even nearly close to completion. Acetylation is emerging as a major regulatory mechanism for metabolism, joining the well-known mechanisms of transcriptional regulation, feedback inhibition, allosteric regulation and phosphorylation. Direct and indirect evidence has shown that acetylation...
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