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Purpose Lysophosphatidic acid (LPA), which activates the small guanosine triphosphate (GTP)-binding protein Rho, was previously shown to promote migration of the rabbit corneal epithelium in culture. The signaling pathway responsible for this effect of LPA was examined in this study with a human corneal epithelial (HCE) cell line. Methods The activation of Rho was detected with a pull-down assay...
Methods. The activation of Rho was detected with a pull-down assay. Tyrosine phosphorylation of paxillin and of focal adhesion kinase (FAK) were examined both by immunofluorescence staining and by immunoprecipitation and immunoblot analyses. Expression of integrins 5 and 1 was evaluated by immunoblot analysis. Results. Incubation of cells with LPA (10M) for 2min resulted in marked activation of Rho,...
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