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Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using comparative callers. However, matched germline samples are frequently not available such as with archival tissues, which makes it...
Résumé Contexte Le diagnostic du cancer peut avoir un impact sur le bien-être des patients. La réaction psychologique fait partie d’une réaction à l’annonce du diagnostic du cancer. Peu de publications abordent la différence entre les sexes en matière de réactions psychologiques à l’annonce d’un diagnostic de cancer et son influence sur la charge psychique liée aux symptômes. L’objectif de l’étude...
In plants and animals, gene expression can be altered by changes not to DNA itself but rather chemical modifications either to DNA or to histones that interact with DNA. These so called epigenetic modifications persist through cell cycle. Rapidly advancing technologies, such next generation DNA sequencing, have dramatically increased our ability to survey epigenetic markers genomewide. These techniques...
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