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BACKGROUND:Gastroesophageal reflux is a risk factor for esophageal adenocarcinoma, and bile acid and its farnesoid X receptor (FXR) have been implicated in esophageal tumorigenesis. The authors investigated the role of FXR expression and activity in esophageal cancer initiation and growth.
METHODS:FXR expression in esophageal adenocarcinoma tissues was assessed by immunohistochemistry. Knockdown...
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