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This randomized, open-label, cross-over study compares the efficacy of mealtime rapid-acting analog insulin aspart with human insulin, in combination with metformin. A total of 30 patients with type 2 diabetes, inadequately controlled (HbA 1c >7.5%) with oral hypoglycemic agents (OHAs), were assigned to human insulin 30min before meals or aspart immediately before meals, both with metformin...
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