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AimThe development of fibrosis is considered an important phase in the progress of non‐alcoholic steatohepatitis (NASH) towards the end stage of liver disease, including cirrhosis. However, few small animal models can display NASH‐associated fibrosis. We aimed to establish a dietary model of NASH with rapid progression to fibrosis using genetically normal rats.
MethodsNine‐week‐old male Sprague–Dawley...
AimInsight into hepatic fibrogenesis and carcinogenesis (fibro‐carcinogenesis) caused by hepatitis C virus (HCV) infection has come from recent analyses of transforming growth factor (TGF)‐β signaling. TGF‐β type I receptor and pro‐inflammatory cytokine‐activated kinases differentially phosphorylate Smad2 and Smad3 to create C‐terminally (C), linker (L) or dually (L/C) phosphorylated (p) isoforms...
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