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AimTo compare the pharmacokinetics of radiofrequency (RF) ablation with chemolipiodolization using cisplatin (CDDP) powder and miriplatin (MPT) in a porcine liver.
MethodsTwelve pigs were divided equally into four groups. After each CDDP powder‐lipiodol suspension (n = 6; groups A and B) or MPT‐lipiodol suspension (n = 6; groups C and D) was injected into the lateral left artery, one RF ablation was...
The 90-kDa heat shock protein (HSP90) is a molecular chaperone that assists in the folding and assembly of proteins in the cytosol. We previously demonstrated that the antineoplastic reagent, cisplatin, inhibits the aggregation prevention activity of mammalian HSP90. We now show that cisplatin binds both the amino terminal and carboxyl terminal domains of the human HSP90 and differently affects these...
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