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Mice that express a dominant-negative form of transforming growth factor-β receptor restricted to T cells (dnTGF-βRII) develop antimitochondrial antibodies and liver inflammation similar to human primary biliary cirrhosis.To address the role of B cells in this model of primary biliary cirrhosis, we bred B cell–deficient mice (Igμ–/–) with dnTGF-βRII mice, creating Igμ–/–dnTGF-βRII mice, and compared...
Background & Aims: Sera from patients with primary biliary cirrhosis (PBC) are characterized by the presence of antimitochondrial antibodies and elevated levels of immunoglobulin (Ig) M. We hypothesized that the increase in serum IgM is the result of chronic B-cell activation induced via the Toll-like receptor (TLR) signaling pathway. Methods: We analyzed peripheral blood mononuclear cells (PBMCs)...
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