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Glial cell line-derived neurotrophic factor (GDNF) is a survival factor for many neuronal cell types and has wide ranging effects within the central nervous system. To investigate the expression of the GDNF gene in immune cell lines under inflammatory conditions, we pharmacologically estimated the induction of GDNF mRNA in RAW264.7 cells. RT-PCR analysis revealed that LPS-induced GDNF mRNA in RAW264...
Glial cell line-derived neurotrophic factor (GDNF), a distant member of the transforming growth factor-β superfamily, was originally purified and cloned as a potent survival factor for midbrain dopaminergic neurons. Some studies have characterized the transcriptional regulation of the GDNF gene, but its regulatory mechanisms have yet to be well defined, especially under pathophysiological conditions...
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