Search results for: Tjalf Ziemssen

Items from 1 to 20 out of 91 results

article

Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance

Tony Sehr, Katja Akgün, Pascal Benkert, Jens Kuhle, more

Journal of Sleep Research > 33 > 5 > n/a - n/a

Obstructive sleep apnea is associated with cognitive impairment and increased risk for neurodegenerative diseases. Obstructive sleep apnea treatment with positive airway pressure therapy helps to improve cognitive symptoms and reduces long‐term dementia risk. To test whether these treatment effects are due to a reduction in neuronal damage, we examined longitudinal changes in the neurodegenerative...

article

Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study

Lukasz Smolinski, Tjalf Ziemssen, Katja Akgun, Agnieszka Antos, more

Movement Disorders > 37 > 12 > 2446 - 2451

Background Although brain atrophy is common in neurological Wilson's disease, longitudinal studies are lacking. Objective The objective of this study was to measure longitudinal brain atrophy rate and to relate it to the change in neurological impairment in Wilson's disease. Methods We included patients with brain imaging done at diagnosis and at least 12 months later. The atrophy rate was measured...

article

Brain structure and neurocognitive function in two professional mountaineers during 35 days of severe normobaric hypoxia

Sven‐Erik Sönksen, Sven Kühn, Mathias Basner, Darius Gerlach, more

European Journal of Neurology > 29 > 10 > 3112 - 3116

Background and purpose Animal studies suggest that exposure to severe ambient hypoxia for several days may have beneficial long‐term effects on neurodegenerative diseases. Because, the acute risks of exposing human beings to prolonged severe hypoxia on brain structure and function are uncertain, we conducted a pilot study in healthy persons. Methods We included two professional mountaineers (participants...

article

Serum Neurofilament Light Chain as a Biomarker of Brain Injury in Wilson's Disease: Clinical and Neuroradiological Correlations

Tjalf Ziemssen, Katja Akgun, Anna Członkowska, Agnieszka Antos, more

Movement Disorders > 37 > 5 > 1074 - 1079

Background Clinical scales and neuroimaging are used to monitor nervous system injury in Wilson's disease, while data on serum markers are scarce. Objective To investigate whether serum concentrations of neurofilament light chain (sNfL) correlate with brain injury in Wilson's disease patients. Methods In 61 treatment‐naïve patients, the Unified Wilson's Disease Rating Scale and a validated semiquantitative...

article

CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study

Darius Häusler, Katja Akgün, Lidia Stork, Hans Lassmann, more

Brain Pathology > 31 > 6 > n/a - n/a

Natalizumab, a recombinant humanized monoclonal antibody directed against the α4 subunit of the integrins α4ß1 and α4ß7, has been approved for the treatment of active relapsing‐remitting MS. Although natalizumab is a highly beneficial drug that effectively reduces the risk of sustained disability progression and the rate of clinical relapses, some patients do not respond to it, and some are at higher...

article

Impedimetric Microfluidic Sensor‐in‐a‐Tube for Label‐Free Immune Cell Analysis

Aleksandr I. Egunov, Zehua Dou, Dmitriy D. Karnaushenko, Franziska Hebenstreit, more

Small > 17 > 5 > n/a - n/a

Analytical platforms based on impedance spectroscopy are promising for non‐invasive and label‐free analysis of single cells as well as of their extracellular matrix, being essential to understand cell function in the presence of certain diseases. Here, an innovative rolled‐up impedimetric microfulidic sensor, called sensor‐in‐a‐tube, is introduced for the simultaneous analysis of single human monocytes...

article

Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis

Holger Schirutschke, Johannes Kochan, Kristin Haink, Ronny Rettig, more

Clinical Physiology and Functional Imaging > 41 > 1 > 42 - 50

Objective Recently, dynamic retinal vessel analysis (DVA) has gained interest for investigation of microvascular function but comparative measurements with standard methods like the forearm blood flow technique (FBF) are uncommon till now. Methods We recruited 23 high‐risk cardiovascular patients (Risk) and 17 healthy persons (Ctrl). During the FBF experiment, postocclusive reactive hyperaemia...

article

Clinical relevance of circadian melatonin release in relapsing-remitting multiple sclerosis

Simone Kern, Michael Geiger, Madlen Paucke, Alina Kästner, more

Journal of Molecular Medicine > 2019 > 97 > 11 > 1547-1555

A growing body of evidence indicates the role of melatonin (MT) in the pathogenesis of multiple sclerosis (MS): It modulates immune function, alleviates oxidative stress and it is linked to seasonality of MS relapse. This report addresses the potential clinical relevance of circadian MT rhythms in relapsing-remitting MS (RRMS) patients. The study sample comprised of fifty-five RRMS patients and fifty...

article

Early central vs. peripheral immunological and neurobiological effects of fingolimod—a longitudinal study

Tony Sehr, Katja Akgün, Undine Proschmann, Robert Bucki, more

Journal of Molecular Medicine > 2019 > 97 > 9 > 1263-1271

Fingolimod (FTY) is known to have multiple effects on the immune system and the central nervous system (CNS) in patients with multiple sclerosis (MS). In this study, we evaluated the immunological and neurobiological effects of FTY in MS. Blood and cerebrospinal fluid (CSF) samples were collected from 15 MS patients before first FTY administration and after 4 months of FTY therapy. Immunophenotyping...

article

How the depth of processing modulates emotional interference – evidence from EEG and pupil diameter data

Marie Luise Schreiter, Witold X. Chmielewski, Moritz Mückschel, Tjalf Ziemssen, more

Cognitive, Affective, & Behavioral Neuroscience > 2019 > 19 > 5 > 1231-1246

The ability to process emotionally conflicting information is an important requirement for emotional self-control. While it seems obvious that the impact of interfering emotional information critically depends on how deeply this interfering information is processed, it is still unknown what cognitive subprocesses are most affected by manipulating the depth of processing of emotionally interfering...

article

Anodal tDCS affects neuromodulatory effects of the norepinephrine system on superior frontal theta activity during response inhibition

Nico Adelhöfer, Moritz Mückschel, Benjamin Teufert, Tjalf Ziemssen, more

Brain Structure and Function > 2019 > 224 > 3 > 1291-1300

Medial and superior frontal theta oscillations are important for response inhibition. The norepinephrine (NE) system has been shown to modulate these oscillations possibly via gain control mechanisms, which depend on the modulation of neuron membrane potentials. Because the latter are also modulated by tDCS, the interrelation of tDCS and NE effects on superior frontal theta band activity needs investigation...

article

Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine

Jeremy Hobart, Tjalf Ziemssen, Peter Feys, Michael Linnebank, more

CNS Drugs > 2019 > 33 > 1 > 61-79

Background Walking impairment is a hallmark of multiple sclerosis (MS). It affects > 90% of individuals over time, reducing independence and negatively impacting health-related quality of life, productivity, and daily activities. Walking impairment is consistently reported as one of the most distressing impairments by individuals with MS. Prolonged-release (PR)-fampridine previously has been shown...

article

Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

Alexander Klistorner, Yi Chai, Letizia Leocani, Philipp Albrecht, more

CNS Drugs > 2018 > 32 > 12 > 1159-1171

Background Multifocal visual evoked potential (MF-VEP) assesses a wider visual field than full-field VEP (FF-VEP) and potentially offers a more precise analysis of optic nerve injury and repair following optic neuritis. MF-VEP may offer advantages over FF-VEP as an endpoint in clinical trials of remyelinating therapies. Objective MF-VEP testing was used to study changes in visual pathways in 48%...

article

Clinical and Demographic Profile of Patients Receiving Fingolimod in Clinical Practice in Germany and the Benefit–Risk Profile of Fingolimod After 1 Year of Treatment: Initial Results From the Observational, Noninterventional Study PANGAEA

Tjalf Ziemssen, Michael Lang, Björn Tackenberg, Stephan Schmidt, more

Neurotherapeutics > 2018 > 15 > 1 > 190-199

The population with multiple sclerosis receiving treatment in clinical practice differs from that in randomized controlled trials (RCTs). An assessment of the real-world benefit–risk profile of therapies is needed. This analysis used data from the large, noninterventional, observational German study Post-Authorization Non-interventional German sAfety study of GilEnyA (PANGAEA) to assess prospectively...

article

The role of phasic norepinephrine modulations during task switching: evidence for specific effects in parietal areas

Nicole Wolff, Moritz Mückschel, Tjalf Ziemssen, Christian Beste

Brain Structure and Function > 2018 > 223 > 2 > 925-940

Cognitive flexibility is a major requirement for successful goal-directed behavior and their neurobiological underpinnings are becoming better understood. However, the role of the norepinephrine system during task switching is largely enigmatic, despite neurobiological considerations make it likely that the norepinephrine system likely plays an important role. Theoretical considerations also suggest...

article

Response to: S. Sega-Jazbec et al.: “Management of infusion related reactions associated with alemtuzumab in patients with multiple sclerosis” Multiple Sclerosis and Related Disorders 2017

Katja Thomas, Tjalf Ziemssen

Multiple Sclerosis and Related Disorders > 2017 > 17 > C > 177-178

article

Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS

Tjalf Ziemssen, Hayrettin Tumani, Tony Sehr, Katja Thomas, more

Journal of Neuroinflammation > 2017 > 14 > 1 > 1-10

Background Laquinimod is an oral immunomodulator in clinical development to treat relapsing-remitting multiple sclerosis (RRMS). Laquinimod is in clinical development for the treatment of multiple sclerosis and Huntington Disease (HD). The objective of this study is to assess the safety, tolerability, pharmacokinetics (PK) and cytoimmunologic effects following escalating doses of laquinimod in patients...

article

Demands on response inhibition processes determine modulations of theta band activity in superior frontal areas and correlations with pupillometry – Implications for the norepinephrine system during inhibitory control

Gabriel Dippel, Moritz Mückschel, Tjalf Ziemssen, Christian Beste

NeuroImage > 2017 > 157 > C > 575-585

Response inhibition processes are important for goal-directed behavior and particularly demanded when it is unlikely to inhibit automatically executed responses. It has been suggested that the norepinephrine (NE) system is important to consider for such likelihood effects. As an indirect measure of the NE system activity we used the pupil diameter and integrated this data with neurophysiological (EEG)...

article

Patients’ preferences for involvement in the decision-making process for treating diabetic retinopathy

Lydia Marahrens, Raimar Kern, Tjalf Ziemssen, Andreas Fritsche, more

BMC Ophthalmology > 2017 > 17 > 1 > 1-9

Background To assess factors associated with the preferred role of the attending ophthalmologist in the decision-making processes before treating diabetic retinopathy (DR). Methods Cross-sectional study of 810 adults attending secondary diabetes care centers (NCT02311504). Diabetes patients were classified using a validated questionnaire in an ophthalmologist-dominant decision-making (ODM), shared...

article

Multiple sclerosis in the real world: A systematic review of fingolimod as a case study

Tjalf Ziemssen, Jennie Medin, C. Anne-Marie Couto, Catherine R. Mitchell

Autoimmunity Reviews > 2017 > 16 > 4 > 355-376

The aim of our study was to systematically review the growing body of published literature reporting on one specific multiple sclerosis (MS) treatment, fingolimod, in the real world to assess its effectiveness in patients with MS, evaluate methodologies used to investigate MS in clinical practice, and describe the evidence gaps for MS as exemplified by fingolimod.We conducted a PRISMA-compliant systematic...

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INFONA - science communication portal

Search results for: Tjalf Ziemssen

Effects of obstructive sleep apnea treatment on neurodegenerative biomarker neurofilament light chain and cognitive performance

Brain Atrophy Is Substantially Accelerated in Neurological Wilson's Disease: A Longitudinal Study

Brain structure and neurocognitive function in two professional mountaineers during 35 days of severe normobaric hypoxia

Serum Neurofilament Light Chain as a Biomarker of Brain Injury in Wilson's Disease: Clinical and Neuroradiological Correlations

CNS inflammation after natalizumab therapy for multiple sclerosis: A retrospective histopathological and CSF cohort study

Impedimetric Microfluidic Sensor‐in‐a‐Tube for Label‐Free Immune Cell Analysis

Comparative study of microvascular function: Forearm blood flow versus dynamic retinal vessel analysis

Clinical relevance of circadian melatonin release in relapsing-remitting multiple sclerosis

Early central vs. peripheral immunological and neurobiological effects of fingolimod—a longitudinal study

How the depth of processing modulates emotional interference – evidence from EEG and pupil diameter data

Anodal tDCS affects neuromodulatory effects of the norepinephrine system on superior frontal theta activity during response inhibition

Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine

Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

Clinical and Demographic Profile of Patients Receiving Fingolimod in Clinical Practice in Germany and the Benefit–Risk Profile of Fingolimod After 1 Year of Treatment: Initial Results From the Observational, Noninterventional Study PANGAEA

The role of phasic norepinephrine modulations during task switching: evidence for specific effects in parietal areas

Response to: S. Sega-Jazbec et al.: “Management of infusion related reactions associated with alemtuzumab in patients with multiple sclerosis” Multiple Sclerosis and Related Disorders 2017

Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS

Demands on response inhibition processes determine modulations of theta band activity in superior frontal areas and correlations with pupillometry – Implications for the norepinephrine system during inhibitory control

Patients’ preferences for involvement in the decision-making process for treating diabetic retinopathy

Multiple sclerosis in the real world: A systematic review of fingolimod as a case study

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