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Previous studies have shown that tumor necrosis factor-alpha (TNF-α) and TNF receptor 1 (TNFR1) in dorsal root ganglia (DRG) and in spinal dorsal horn are upregulated after nerve injury and that many TNF-α-containing neurons overexpress TNFR1. In the present study, we found that peri-sciatic administration of rat recombinant TNF-α (rrTNF) at the concentrations of 10, 100 and 1000 pg/ml (daily for...
Compelling evidence shows that the adjacent uninjured primary afferents play an important role in the development of neuropathic pain after nerve injury. The underlying mechanisms, however, are largely unknown. In the present study, the selective motor fiber injury was performed by L5 ventral root transection (L5 VRT), and p38 activation in dorsal root ganglia (DRG) and L5 spinal dorsal horn was examined...
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