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Phospholipase Cζ (PLCζ) is a sperm-specific PLC capable of causing repetitive intracellular Ca 2+ ([Ca 2+ ] i ) release ([Ca 2+ ] i oscillations) in mammalian eggs. Accumulating evidence suggests that PLCζ is the sperm factor responsible for inducing egg activation. Nevertheless, some sperm fractions devoid of 72-kDa PLCζ showed [Ca 2+ ] i oscillation-inducing...
Sperm entry in mammalian eggs initiates oscillations in the concentration of free calcium ([Ca 2+ ] i ). In mouse eggs, oscillations start at metaphase II (MII) and conclude as the zygotes progress into interphase and commence pronuclear (PN) formation. The inositol 1,4,5-trisphosphate receptor (IP 3 R-1), which underlies the oscillations, undergoes degradation during this...
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