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14‐3‐3 proteins bind and modulate the activities of a wide variety of phosphoproteins. Crystal structures of 14‐3‐3 isoforms bound to phospholigands have identified several residues important for ligand binding. Here, we report the role of two invariant residues, D124 and E131, in peptide binding and peptide‐induced conformational changes of the binding pocket. Surprisingly, the D124A mutation abrogates...
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