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Bisphosphonates (BPs) have been commonly used in the treatment of osteolytic bone lesions, such as osteoporosis and osteogenesis imperfecta. However, serious side‐effects can occur during the therapy. To search for novel potent BPs with lower side‐effects, a series of imidazole‐containing BPs (zoledronic acid [ZOL]; ZOL derivatives by substitution of the hydrogen at the 2‐position on the imidazole...
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