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Background and Purpose
Recent studies reported therapeutic effects of monotherapy with either tumour suppressor p53 (p53) agonist or hypoxia‐inducible factor 2α (HIF‐2α) antagonist for pulmonary hypertension (PH). This study investigated whether a combined treatment of p53 agonist, Nutlin3a, and HIF‐2α antagonist, PT2385, would be more effective than monotherapy, based on the cell type‐divergent...
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