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A biocompatible and modifiable protein nanocarrier is a promising candidate for tumor targeted drug delivery. However, it is challenging to effectively load hydrophobic drugs, not to mention to upload both hydrophilic and hydrophobic drugs on one protein nanocarrier. Here, an amphiphilic multi‐drug loading protein nanocage (Am‐PNCage) is presented which is generated by replacing the fifth helix of...
In article number 2102004, Xiyun Yan, Kelong Fan, and co‐workers present an amphiphilic multi‐drug loading protein nanocage (Am‐PNCage) with a dual‐tumor targeting (CD71 and Integrin) property, which exhibits a spatiotemporally programmed cascade drug release pattern and kills drug‐resistant tumor cells synergistically. It represents a novel promising protein cage nanocarrier platform for co‐loading...
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