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Irreversible electroporation (IRE) is a technique to kill cells by delivering a series of short-duration, high voltage square wave electric pulses into tissue to alter the native cellular transmembrane potential, creating irrecoverable nanoscale defects in the cell membrane. IRE protocols constrain Joule heating below temperatures that cause coagulation of extracellular proteins, and consequently...
Irreversible electroporation (IRE) ablation uses brief electric pulses to kill a volume of tissue without damaging the structures contraindicated for surgical resection or thermal ablation, including blood vessels and ureters. IRE offers a targeted nephron-sparing approach for treating kidney tumors, but the relevant organ-specific electrical properties and cellular susceptibility to IRE electric...
Electroporation uses short, pulsed electric fields to induce a cellular transmembrane potential that results in increased cellular permeability. When performed irreversibly, it results in cell death while leaving the extracellular matrix and other sensitive structures intact. These electric fields result in thermal effects to the affected tissues due to resistive heating. We measure this heating extent...
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