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The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over the past decade. As a nonthermal therapy, IRE offers several potential benefits over other focal therapies, which include 1) short treatment delivery time, 2) reduced collateral thermal injury, and 3) the ability to treat tumors adjacent to major blood vessels. These advantages have stimulated widespread...
Cells exposed to short electric pulses experience a change in their transmembrane potential, which can lead to increased membrane permeability of the cell. When the energy of the pulses surpasses a threshold, the cell dies in a non-thermal manner known as irreversible electroporation (IRE). IRE has shown promise in the focal ablation of pathologic tissues. Its non-thermal mechanism spares sensitive...
Electroporation uses short, pulsed electric fields to induce a cellular transmembrane potential that results in increased cellular permeability. When performed irreversibly, it results in cell death while leaving the extracellular matrix and other sensitive structures intact. These electric fields result in thermal effects to the affected tissues due to resistive heating. We measure this heating extent...
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