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Guanosine derivatives are important for diagnosis of oxidative DNA damage including 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) as one of the most abundant products of DNA oxidation. This compound is commonly determined in urine, which makes 8‐OHdG a good non‐invasive marker of oxidation stress. In this study, we optimized and tested the isolation of 8‐OHdG from biological matrix by using paramagnetic particles...
Metallothioneins (MTs) are a family of ubiquitous, biologically interesting proteins that have been isolated and studied in a wide variety of organisms, including prokaryotes, plants, invertebrates and vertebrates. Due to the property of MTs being metal-inducible and their high affinity to metal ions, homeostasis of heavy-metal levels is probably their most important biological function.MTs are also...
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