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BACKGROUNDAutologous stem cell transplantation (SCT) is a common management strategy for select patients with immunoglobulin light‐chain amyloidosis, but no trials have documented improved overall survival.
METHODSEighty‐nine patients with biopsy‐proven immunoglobulin light‐chain amyloidosis were allowed to select treatment with melphalan plus dexamethasone (n = 34) or SCT (n = 55); all patients...
All patients with proven light chain amyloidosis deserve a trial of therapy. Although high dose therapy has been shown to be highly effective, only a quarter of patients are actually eligible for this technique. Lower intensity treatments are required for the majority of patients. We review the history of treatment of amyloidosis beginning with the use of conventional alkylating agent chemotherapy,...
Dexamethasone (Dex), alone or in combination, is commonly used for treating multiple myeloma. Dex as single agent for initial therapy of myeloma results in overall response rates of 50–60%. It is unclear whether steroid responsiveness reflects any biological characteristic that impacts long‐term outcome. We studied a cohort of 182 patients with newly diagnosed myeloma seen between March 1998 and June...
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