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Background
Sarcopenia increases with age and is associated with poor survival outcomes in patients with cancer. By using a deep learning–based segmentation approach, clinical computed tomography (CT) images of the abdomen of patients with newly diagnosed multiple myeloma (NDMM) were reviewed to determine whether the presence of sarcopenia had any prognostic value.
Methods
Sarcopenia was detected...
Background
There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population‐based analysis of long‐term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT).
Methods
The National Cancer Data Base is a US cancer database of approximately 34 million patients from >1500...
BACKGROUNDAutologous stem cell transplantation (SCT) is a common management strategy for select patients with immunoglobulin light‐chain amyloidosis, but no trials have documented improved overall survival.
METHODSEighty‐nine patients with biopsy‐proven immunoglobulin light‐chain amyloidosis were allowed to select treatment with melphalan plus dexamethasone (n = 34) or SCT (n = 55); all patients...
BACKGROUND:The current study was conducted to determine characteristics distinguishing the 10‐year survivor group in patients with systemic immunoglobulin light chain (AL) amyloidosis who underwent autologous stem cell transplantation (SCT).
METHODS:The study group included all 74 patients with AL amyloidosis who underwent high‐dose melphalan treatment supported by autologous SCT since the beginning...
BACKGROUND:Early versus delayed autologous stem cell transplantation (SCT) results in comparable overall survival in patients with multiple myeloma (MM) who receive alkylator‐based therapies. It is not clear whether this paradigm holds true in the context of new therapies, such as immunomodulatory drugs (IMiDs).
METHODS:The authors studied 290 patients with untreated MM who received IMiD‐based initial...
BACKGROUND:Currently used treatment response criteria in multiple myeloma (MM) are based in part on serum monoclonal protein (M‐protein) measurements. A drawback of these criteria is that response is determined solely by the best level of M‐protein reduction, without considering the serial trend. The authors hypothesized that metrics incorporating the serial trend of M‐protein would be better predictors...
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